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PD153035 (Hydrochloride)

PD153035 Hydrochloride (SU-5271 Hydrochloride) is a potent EGFR inhibitor with Ki and IC50 of 6 and 25 pM, respectively.

Product Specifications

CAS Number

183322-45-4

Product Name Alternative

SU-5271 (Hydrochloride) ; AG1517 (Hydrochloride) ; ZM 252868 (Hydrochloride)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

EGFR

Type

Reference compound

Related Pathways

JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/PD153035-Hydrochloride.html

Concentration

10mM

Purity

99.48

Solubility

DMSO : 4 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

COC1=C(C=C(C2=C1)N=CN=C2NC3=CC(Br)=CC=C3)OC.Cl

Molecular Formula

C16H15BrClN3O2

Molecular Weight

396.67

Precautions

H302, H315, H319, H335

References & Citations

[1]Bridges AJ, et al. Tyrosine kinase inhibitors. 8. An unusually steep structure-activity relationship for analogues of 4- (3-bromoanilino) -6,7-dimethoxyquinazoline (PD 153035), a potent inhibitor of the epidermal growth factor receptor. J Med Chem. 1996 Jan 5;39 (1) :267-76.|[2]Fry DW, et al. A specific inhibitor of the epidermal growth factor receptor tyrosine kinase. Science. 1994 Aug 19;265 (5175) :1093-5.|[3]Bos M, et al. PD153035, a tyrosine kinase inhibitor, prevents epidermal growth factor receptoractivation and inhibits growth of cancer cells in a receptor number-dependent manner. Clin Cancer Res. 1997 Nov;3 (11) :2099-106.|[4]Kunkel MW, et al. Inhibition of the epidermal growth factor receptor tyrosine kinase by PD153035 in human A431 tumors in athymic nude mice. Invest New Drugs. 1996;13 (4) :295-302.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

EGFR/ErbB1/HER1

Citation 01

BioRxiv. 2024 Apr 4.|Biochim Biophys Acta Mol Basis Dis. 2024 Mar;1870 (3) :166981.|bioRxiv. 2025 January 18.|Cell Death Dis. 2022 Jul 25;13 (7) :647.|Elife. 2015 Feb 10:4:e05178.|Gen Comp Endocrinol. 2020 Dec 1;299:113616.|Int J Stem Cells. 2022 Nov 30;15 (4) :347-358.|J Toxicol Sci. 2023 Nov 14;48 (12) :655-663.|Nat Commun. 2018 Jun 5;9 (1) :2174.|Sci Rep. 2025 Nov 17;15 (1) :40227.

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