Recombinant Human 5'-nucleotidase/CD73/NT5E Protein (His Tag)

<strong>Recombinant Human 5'-nucleotidase/CD73/NT5E Protein (His Tag)</strong>_x000D_ <strong>Catalog number:</strong> B2019130_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 10 µg_x000D_ <strong>Molecular Weight or Concentration:</strong> 59.2 kDa_x000D_ <strong>Supplied as:</strong> Powder_x000D_ <strong>Applications:</strong> a molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> −20°C_x000D_ <strong>Keywords:</strong> CALJA Protein, Human; CD73 Protein, Human; E5NT Protein, Human; eN Protein, Human; eNT Protein, Human; NT Protein, Human; NT5 Protein, Human; NTE Protein, Human_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Yu J, Wang X, Lu Q, Wang J, Li L, Liao X, Zhu W, Lv L, Zhi X, Yu J, Jin Y, Zou Q, Ou Z, Liu X, Zhou P. Extracellular 5'-nucleotidase (CD73) promotes human breast cancer cells growth through AKT/GSK-3β/β-catenin/cyclinD1 signaling pathway Int J Cancer. 2018 Mar 1;142(5):959-967._x000D_ 2: Ghoteimi R, Braka A, Rodriguez C, Cros-Perrial E, Duvauchelle V, Uttaro JP, Mathé C, Ménétrier-Caux C, Jordheim LP, Chaloin L, Peyrottes S. Second-Generation CD73 Inhibitors Based on a 4,6-Biaryl-2-thiopyridine Scaffold ChemMedChem. 2023 Apr 3;18(7):e202200594._x000D_ 3: Hesse J, Rosse MK, Steckel B, Blank-Landeshammer B, Idel S, Reinders Y, Sickmann A, Sträter N, Schrader J. Mono-ADP-ribosylation sites of human CD73 inhibit its adenosine-generating enzymatic activity Purinergic Signal. 2022 Mar;18(1):115-121._x000D_ 4: Knapp KM, Zebisch M, Sträter N. Crystallization and preliminary X-ray analysis of the open form of human ecto-5'-nucleotidase (CD73) Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Dec 1;68(Pt 12):1545-9._x000D_ 5: Rahimova R, Fontanel S, Lionne C, Jordheim LP, Peyrottes S, Chaloin L. Identification of allosteric inhibitors of the ecto-5'-nucleotidase (CD73) targeting the dimer interface PLoS Comput Biol. 2018 Jan 29;14(1):e1005943._x000D_ 6: Wu R, Chen Y, Li F, Li W, Zhou H, Yang Y, Pei Z. Effects of CD73 on human colorectal cancer cell growth in vivo and in vitro Oncol Rep. 2016 Mar;35(3):1750-6._x000D_ 7: Ghoteimi R, Nguyen VT, Rahimova R, Grosjean F, Cros-Perrial E, Uttaro JP, Mathé C, Chaloin L, Jordheim LP, Peyrottes S. Synthesis of Substituted 5'-Aminoadenosine Derivatives and Evaluation of Their Inhibitory Potential toward CD73 ChemMedChem. 2019 Aug 6;14(15):1431-1443._x000D_ 8: Nishimoto S, Mizuno T, Takahashi K, Nagano F, Yuzawa Y, Nishiyama A, Osafune K, Hitomi H, Nagamatsu T. CD140b and CD73 are markers for human induced pluripotent stem cell-derived erythropoietin-producing cells FEBS Open Bio. 2020 Mar;10(3):427-433._x000D_ 9: Allard B, Cousineau I, Spring K, Stagg J. Measurement of CD73 enzymatic activity using luminescence-based and colorimetric assays Methods Enzymol. 2019;629:269-289._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/33052071">10: Zhong EH, Ledderose C, De Andrade Mello P, Enjyoji K, Lunderberg JM, Junger W, Robson SC. Structural and functional characterization of engineered bifunctional fusion proteins of CD39 and CD73 ectonucleotidases Am J Physiol Cell Physiol. 2021 Jan 1;320(1):C15-C29. </a>_x000D_ _x000D_ <strong>Products Related to Recombinant Human 5'-nucleotidase/CD73/NT5E Protein (His Tag) can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>