Neocryptotanshinone

Neocryptotanshinone, a fatty diterpenoids from Salvia Miltiorrhiza, inhibits lipopolysaccharide-induced inflammation by suppression of NF-κB and iNOS signaling pathways[1][2].

Product Specifications

CAS Number

[109664-02-0]

UNSPSC

12352005

Hazard Statement

H315, H319

Target

NF-κB; NO Synthase

Type

Natural Products

Related Pathways

Immunology/Inflammation; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/neocryptotanshinone.html

Purity

98.82

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1C([C@@H](C)CO)=C(O)C(C2=C1C=CC3=C2CCCC3(C)C)=O

Molecular Formula

C19H22O4

Molecular Weight

314.38

Precautions

H315, H319

References & Citations

[1]Chuanhong Wu, et al. Neocryptotanshinone Inhibits Lipopolysaccharide-Induced Inflammation in RAW264.7 Macrophages by Suppression of NF-κB and iNOS Signaling Pathways. Acta Pharm Sin B. 2015 Jul;5 (4) :323-9.|[2]H C Lin, et al. Two New Fatty Diterpenoids From Salvia Miltiorrhiza. J Nat Prod. 2001 May;64 (5) :648-50.|[3]FENG Jinghui, et al. Effects of Salvia miltiorrhiza Bunge extract and its single components on monosodium urate-induced pain in vivo and lipopolysaccharide-induced inflammation in vitro. J Tradit Chin Med. 2021. 41 (2) : 219-226.