Mephenesin-d3
Mephenesin-d3 is deuterium labeled Mephenesin. Mephenesin is an NMDA receptor antagonist. Mephenesin is also a central muscle relaxant with antianxiety, muscle-paralyzing and anticonvulsant effects. Mephenesin acts directly on the skeletal muscle fibres to produce skeletal muscle relaxation. Mephenesin is promising for research of spasticity or painful muscle spasm[1][2][3][4][5][6].
Product Specifications
UNSPSC
12352005
Target
IGluR; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling; Others
Field of Research
Neurological Disease
Smiles
OCC(O)COC1=CC=CC=C1C([2H])([2H])[2H]
Molecular Formula
C10H11D3O3
Molecular Weight
185.23
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Crankshaw DP, et al. Mephenesin, methocarbamol, chlordiazepoxide and diazepam: actions on spinal reflexes and ventral root potentials. Br J Pharmacol. 1970 Jan;38 (1) :148-56.|[3]Mephenesin: abuse and dependence. Prescrire Int. 2013 May;22 (138) :127-128.|[4]Ludwig B J, et al. Muscle-paralyzing compounds related to mephenesin[J]. Journal of the American Chemical Society, 1952, 74 (8) : 1935-1939.|[5]?cija P, et al. Conformational flexibility of mephenesin. J Phys Chem B. 2014 May 22;118 (20) :5357-5364.|[6]DIAZ-RIVERA RS, et al. Muscular relaxation in tetanus with special reference to the effect of mephenesin. Ann Intern Med. 1954 Mar;40 (3) :563-80.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
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