Recombinant Human Cu/Zn Superoxide Dismutase Monomer
Recombinant Human Cu/Zn Superoxide Dismutase Monomer
Product Specifications
CAS Number
9000-83-3
Product Name Alternative
SOD1
Gene Name
SOD1
UniProt
P00441
Cellular Locus
Cytoplasm , Mitochondrion , Nucleus , Note=Predominantly cytoplasmic; the pathogenic variants ALS1 Arg-86 and Ala-94 gradually aggregates and accumulates in mitochondria.
Reactivity
Human
Target Antigen
Superoxide dismutase [Cu-Zn]
Target
Cu/Zn Syperoxide Dismutase Monomer
Type
Protein
Applications
WB
Concentration
Lot Specific
Dilution
Dilute in PBS or medium that is identical to that used in the assay system.
Form
Liquid
Buffer
20 mM Tris
Function
Destroys radicals which are normally produced within the cells and which are toxic to biological systems. {PubMed:24140062}.
Storage Conditions
Store at 4°C if entire vial will be used within 2-4 weeks. Store at -20°C for longer periods of time. Addition of a carrier protein (0.1% HSA or BSA) is recommended for long-term storage. Avoid multiple freeze-thaw cycles.
Specificity
Cu/Zn Syperoxide Dismutase Monomer
Formulation
Sterile-filtered solution in 20mM Tris-HCl, pH 7.5 and 10% glycerol.
Buffer pH
pH 7.5
Target Background
Cu/Zn Superoxide Dismutase (SOD1) catalyzes the reaction between superoxide anions and hydrogen to yield molecular oxygen and hydrogen peroxide. It protects a cell from dangerous levels of superoxide. SOD1 binds copper and zinc ions and is one of three isozymes responsible for destroying free superoxide radicals. Mutations in SOD1 cause a form of familial amyotrophic lateral sclerosis (ALS).
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