Delcasertib (hydrochloride)

Delcasertib (KAI-9803) hydrochloride is a potent and selective δ-protein kinase C (δPKC) inhibitor. Delcasertib (KAI-9803) hydrochloride could ameliorate injury associated with ischemia and reperfusion in animal models of acute myocardial infarction (MI) [1][2].

Product Specifications

Product Name Alternative

KAI-9803 (hydrochloride) ; BMS-875944 (hydrochloride)

UNSPSC

12352209

Target

PKC

Type

Peptides

Related Pathways

Epigenetics; TGF-beta/Smad

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/delcasertib-hydrochloride.html

Purity

99.73

Solubility

H2O : 100 mg/mL (ultrasonic)

Smiles

OC(C=C1)=CC=C1C[C@H](NC([C@H](CO)NC([C@H](CC(N)=O)NC([C@@H](NC([C@H](CO)NC([C@@H](N)CSSC[C@H](N)C(N[C@H](C(NCC(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(O)=O)CCCNC(N)=N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC2=CC=C(C=C2)O)=O)=O)=O)CC3=CC=CC=C3)=O)=O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC(C)C)C(NCC(N[C@H](CO)C(N[C@@H](C(O)=O)CC(C)C)=O)=O)=O)=O)=O.[H]Cl

Molecular Formula

C120H200ClN45O34S2

Molecular Weight

2916.74

References & Citations

[1]Miyaji Y, et al. Distribution of KAI-9803, a novel δ-protein kinase C inhibitor, after intravenous administration to rats. Drug Metab Dispos. 2011 Oct;39 (10) :1946-53.|[2]Bates E, et al. Intracoronary KAI-9803 as an adjunct to primary percutaneous coronary intervention for acute ST-segment elevation myocardial infarction. Circulation. 2008 Feb 19;117 (7) :886-96.