MGAT2-IN-5
MGAT2-IN-5 (Compound 17b) is a selective inhibitor for mouse GABA transit protection subsidity 2 (mGAT2) with an IC50 of 45 μM. MGAT2-IN-5 exhibits anticonvulsive efficacy in audiogenic seizure (AGS) susceptible frings mouse model with an ED50 of 20.4 mg/kg[1].
Product Specifications
CAS Number
1426208-69-6
UNSPSC
12352100
Target
GABA Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/mgat2-in-5.html
Smiles
O=C(C1=CCCCC1N(CC/C=C(C2=C(C)C=CS2)\C3=C(C)C=CS3)C)O
Molecular Formula
C22H27NO2S2
Molecular Weight
401.59
References & Citations
[1]Vogensen SB, et al., Selective mGAT2 (BGT-1) GABA uptake inhibitors: design, synthesis, and pharmacological characterization. J Med Chem. 2013 Mar 14;56 (5) :2160-4.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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