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Proxyfan (Oxalate)

Proxyfan Oxalate is a potent histamine H3 receptor antagonist with Ki values of 2.9 nM and 2.7 nM for rat and human H3 receptor, respectively. Proxyfan Oxalate is over 1000-fold more potent at H3 receptors than other histamine receptors[1][2].

Product Specifications

CAS Number

1620017-81-3

UNSPSC

12352005

Target

Histamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/proxyfan-oxalate.html

Smiles

O=C(O)C(O)=O.C1(CCCOCC2=CC=CC=C2)=CNC=N1

Molecular Formula

C15H18N2O5

Molecular Weight

306.31

References & Citations

[1]X Ligneau, et al. Distinct pharmacology of rat and human histamine H (3) receptors: role of two amino acids in the third transmembrane domain. Br J Pharmacol. 2000 Dec;131 (7) :1247-50. |[2]R H Clapp, et al. Proxyfan acts as a neutral antagonist of histamine H3 receptors in the feeding-related hypothalamic ventromedial nucleus. Br J Pharmacol. 2012 Nov;167 (5) :1099-110.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

H3 Receptor

Frequently Asked Questions

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