Proxyfan (Oxalate)
Proxyfan Oxalate is a potent histamine H3 receptor antagonist with Ki values of 2.9 nM and 2.7 nM for rat and human H3 receptor, respectively. Proxyfan Oxalate is over 1000-fold more potent at H3 receptors than other histamine receptors[1][2].
Product Specifications
CAS Number
1620017-81-3
UNSPSC
12352005
Target
Histamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/proxyfan-oxalate.html
Smiles
O=C(O)C(O)=O.C1(CCCOCC2=CC=CC=C2)=CNC=N1
Molecular Formula
C15H18N2O5
Molecular Weight
306.31
References & Citations
[1]X Ligneau, et al. Distinct pharmacology of rat and human histamine H (3) receptors: role of two amino acids in the third transmembrane domain. Br J Pharmacol. 2000 Dec;131 (7) :1247-50. |[2]R H Clapp, et al. Proxyfan acts as a neutral antagonist of histamine H3 receptors in the feeding-related hypothalamic ventromedial nucleus. Br J Pharmacol. 2012 Nov;167 (5) :1099-110.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
H3 Receptor
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