HPK1-IN-3
Product Specifications
UNSPSC Description
HPK1-IN-3 is a potent and selective ATP-competitive hematopoietic progenitor kinase 1 (HPK1; MAP4K1) inhibitor with an IC50 of 0.25 nM. HPK1-IN-3 has IL-2 cellular potency with an EC50 of 108 nM in human peripheral blood mononuclear cells (PBMCs)[1].
Target Antigen
MAP4K
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/hpk1-in-3.html
Smiles
COC1=C(NC2=NC=C(C(N)=O)C(NC3=C(F)C=CC=C3C(F)(F)F)=N2)C=C4CN(C)CCC4=C1
Molecular Weight
490.45
References & Citations
[1]Brandon A Vara, et al. Discovery of Diaminopyrimidine Carboxamide HPK1 Inhibitors as Preclinical Immunotherapy Tool Compounds. ACS Med Chem Lett. 2021 Mar 19;12(4):653-661.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-138568/HPK1-IN-3-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-138568/HPK1-IN-3-SDS-MedChemExpress.pdf
CAS Number
2739844-34-7
Available Sizes
Curated Selection
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