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Anti-Rat TCR alpha/beta Antibody (R73)

Anti-Rat TCR alpha/beta Antibody (R73) is an anti-mouse TCR alpha/beta IgG1 monoclonal antibody. Anti-Rat TCR alpha/beta Antibody (R73) suppresses immune response by depleting α/β+ T cells. Anti-Rat TCR alpha/beta Antibody (R73) can inhibit the expression of pro-inflammatory cytokines. Anti-Rat TCR alpha/beta Antibody (R73) can extend graft survival time by reducing infiltration of T cells and neutrophils. Anti-Rat TCR alpha/beta Antibody (R73) can be used for researches on inflammation, metabolic conditions and xenotransplantation such as arthritis, acute inflammatory peripheral neuropathy and diabetes[1][2][3][4].

Product Specifications

CAS Number

9007-83-4

UNSPSC

12352203

Target

MHC

Type

Inhibitory Antibodies

Related Pathways

Immunology/Inflammation

Field of Research

Metabolic Disease; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/anti-rat-tcr-alpha-beta-antibody-r73.html

Solubility

10 mM in DMSO

Smiles

[Anti-RatTCRalpha/betaAntibody(R73)]

Molecular Weight

(150 kDa)

References & Citations

[1]Yoshino S, et al. Depletion of alpha/beta T cells by a monoclonal antibody against the alpha/beta T cell receptor suppresses established adjuvant arthritis, but not established collagen-induced arthritis in rats. J Exp Med. 1992 Apr 1;175 (4) :907-15.|[2]Jörns A, et al. Remission of autoimmune diabetes by anti-TCR combination therapies with anti-IL-17A or/and anti-IL-6 in the IDDM rat model of type 1 diabetes. BMC Med. 2020 Feb 28;18 (1) :33. |[3]Heidecke CD, et al. Importance of T cells to accelerated rejection and acceptance of renal allografts in sensitized rat recipients. Transplantation. 1998 Nov 27;66 (10) :1354-61. |[4]ung S, et al. Prevention and therapy of experimental autoimmune neuritis by an antibody against T cell receptors-alpha/beta. J Immunol. 1992 Jun 15;148 (12) :3768-75.

Shipping Conditions

Room temperature

Scientific Category

Inhibitory Antibodies

Clinical Information

No Development Reported

Frequently Asked Questions

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