(S, R, S) -AHPC-Me (dihydrochloride)
(S, R, S) -AHPC-Me dihydrochloride (VHL ligand 2 dihydrochloride) is the (S, R, S) -AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein[1]. (S, R, S) -AHPC-Me dihydrochloride can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC50 [2].
Product Specifications
CAS Number
2504950-56-3
Product Name Alternative
VHL ligand 2 (dihydrochloride) ; E3 ligase Ligand 1 (dihydrochloride)
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Ligands for E3 Ligase
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/E3_ligase_Ligand_1_dihydrochloride.html
Purity
99.84
Solubility
DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 100 mg/mL (ultrasonic)
Smiles
N[C@@H](C(C)(C)C)C(N1[C@H](C(N[C@@H](C)C2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O.Cl.Cl
Molecular Formula
C23H34Cl2N4O3S
Molecular Weight
517.51
Precautions
H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Von Hippel-Lindau (VHL)
Available Sizes
Frequently Asked Questions
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