Mambalgin-1

<strong>Mambalgin-1</strong> <strong>Catalog number:</strong> MDP0827 <strong>CAS Number: </strong>3934-29-0 <strong>Sequence: </strong>Leu-Lys-Cys-Tyr-Gln-His-Gly-Lys-Val-Val-Thr-Cys-His-Arg-Asp-Met-Lys-Phe-Cys-Tyr-His-Asn-Thr-Gly-Met-Pro-Phe-Arg-Asn-Leu-Lys-Leu-Ile-Leu-Gln-Gly-Cys-Ser-Ser-Ser-Cys-Ser-Glu-Thr-Glu-Asn-Asn-Lys-Cys-Cys-Ser-Thr-Asp-Arg-Cys-Asn-Lys (Predicted disulfide bonds between Cys3-Cys19, Cys12-Cys37, Cys41-Cys49, and Cys50-Cys55) <strong>Amount:</strong> 100 ug <strong>Molecular Weight:</strong> 6554.4 g/mol <strong>Supplied as:</strong> Powder <strong>Applications:</strong> molecular tool for various biochemical applications <strong>Storage:</strong> -20 °C <strong>WARNING:</strong> For in vitro Research Use Only. NOT for use on humans or animals. <strong>Grade:</strong> Biotechnology grade. All products are highly pure. <strong>References:</strong> 1: Salinas M, Kessler P, Douguet D, Sarraf D, Tonali N, Thai R, Servent D, Lingueglia E. Mambalgin-1 pain-relieving peptide locks the hinge between α4 and α5 helices to inhibit rat acid-sensing ion channel 1a Neuropharmacology. 2021 Mar 1;185:108453. 2: Khezri G, Baghban Kohneh Rouz B, Ofoghi H, Davarpanah SJ. Heterologous expression of biologically active Mambalgin-1 peptide as a new potential anticancer, using a PVX-based viral vector in Nicotiana benthamiana Plant Cell Tissue Organ Cult. 2020;142(2):241-251. 3: Mourier G, Salinas M, Kessler P, Stura EA, Leblanc M, Tepshi L, Besson T, Diochot S, Baron A, Douguet D, Lingueglia E, Servent D. Mambalgin-1 Pain-relieving Peptide, Stepwise Solid-phase Synthesis, Crystal Structure, and Functional Domain for Acid-sensing Ion Channel 1a Inhibition J Biol Chem. 2016 Feb 5;291(6):2616-29. 4: Sun D, Yu Y, Xue X, Pan M, Wen M, Li S, Qu Q, Li X, Zhang L, Li X, Liu L, Yang M, Tian C. Cryo-EM structure of the ASIC1a-mambalgin-1 complex reveals that the peptide toxin mambalgin-1 inhibits acid-sensing ion channels through an unusual allosteric effect Cell Discov. 2018 Jun 5;4:27. 5: Lan H, Wu K, Zheng Y, Pan M, Huang YC, Gao S, Zheng QY, Zheng JS, Li YM, Xiao B, Liu L. Total synthesis of mambalgin-1/2/3 by two-segment hydrazide-based native chemical ligation J Pept Sci. 2016 May;22(5):320-6. 6: Pan M, He Y, Wen M, Wu F, Sun D, Li S, Zhang L, Li Y, Tian C. One-pot hydrazide-based native chemical ligation for efficient chemical synthesis and structure determination of toxin Mambalgin-1 Chem Commun (Camb). 2014 Jun 4;50(44):5837-9. 7: Verkest C, Piquet E, Diochot S, Dauvois M, Lanteri-Minet M, Lingueglia E, Baron A. Effects of systemic inhibitors of acid-sensing ion channels 1 (ASIC1) against acute and chronic mechanical allodynia in a rodent model of migraine Br J Pharmacol. 2018 Nov;175(21):4154-4166. 8: Salinas M, Besson T, Delettre Q, Diochot S, Boulakirba S, Douguet D, Lingueglia E. Binding site and inhibitory mechanism of the mambalgin-2 pain-relieving peptide on acid-sensing ion channel 1a J Biol Chem. 2014 May 9;289(19):13363-73. 9: Wen M, Guo X, Sun P, Xiao L, Li J, Xiong Y, Bao J, Xue T, Zhang L, Tian C. Site-specific fluorescence spectrum detection and characterization of hASIC1a channels upon toxin mambalgin-1 binding in live mammalian cells Chem Commun (Camb). 2015 May 11;51(38):8153-6. <a href="https://pubmed.ncbi.nlm.nih.gov/31824248">10: Chang CT, Fong SW, Lee CH, Chuang YC, Lin SH, Chen CC. Involvement of Acid-Sensing Ion Channel 1b in the Development of Acid-Induced Chronic Muscle Pain Front Neurosci. 2019 Nov 22;13:1247. </a> <br><strong>Products Related to Mambalgin-1 can be found at</strong> <a href="https://moleculardepot.com/product-category/Peptides/"> Peptides</a>