4F 4PP (oxalate)

4F 4PP (oxalate) is a selective 5-HT2A antagonist with almost as high affinity (Ki= 5.3 nM) as ketanserin but with a much lower affinity for 5-HT2C sites (Ki= 620 nM) [1][2][3][4].

Product Specifications

CAS Number

[144734-36-1]

UNSPSC

12352005

Hazard Statement

H315, H319

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/4f-4pp-oxalate.html

Purity

98.86

Solubility

DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C1=CC=C(F)C=C1)C2CCN(CCCCC3=CC=CC=C3)CC2.O=C(O)C(O)=O

Molecular Formula

C24H28FNO5

Molecular Weight

429.48

Precautions

H315, H319

References & Citations

[1]Aira Z, et al. Selective impairment of spinal mu-opioid receptor mechanism by plasticity of serotonergic facilitation mediated by 5-HT2A and 5-HT2B receptors. Pain. 2012;153 (7) :1418-1425.|[2]Lee SH, et al. Peripheral serotonin receptor 2B and transient receptor potential channel 4 mediate pruritus to serotonergic antidepressants in mice. J Allergy Clin Immunol. 2018;142 (4) :1349-1352.e16.|[3] Rodríguez-Muñoz M, et al. Fenfluramine diminishes NMDA receptor-mediated seizures via its mixed activity at serotonin 5HT2A and type 1 sigma receptors. Oncotarget. 2018;9 (34) :23373-23389. Published 2018 May 4.|[4]Gerhold KJ, et al. Pronociceptive and Antinociceptive Effects of Buprenorphine in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude. J Neurosci. 2015;35 (26) :9580-9594.