(+) -Niguldipine (hydrochloride)

(+) -Niguldipine hydrochloride is an antagonist for calcium channel. (+) -Niguldipine hydrochloride produces vasodilation by blocking calcium channels and reducing the transmembrane influx of calcium ions. (+) -Niguldipine hydrochloride inhibits U-46619 (HY-108566) -induced coronary vasoconstriction in guinea pig Langendorff heart with pID50 of 11.37, binds to calcium channel on guinea pig skeletal muscle membrane with Ki of 9.75, and lowers the blood pressure in spontaneously hypertensive rat with pED30 of 7.1. (+) -Niguldipine hydrochloride ameliorates cardiovascular diseases such as hypertension, angina pectoris and arrhythmias[1].

Product Specifications

CAS Number

[113145-69-0]

Product Name Alternative

(S) -Niguldipine (hydrochloride)

UNSPSC

12352005

Target

Calcium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/plus-niguldipine-hydrochloride.html

Purity

98.06

Smiles

O=C(C1=C(C)NC(C)=C(C(OC)=O)[C@@H]1C2=CC=CC([N+]([O-])=O)=C2)OCCCN3CCC(C4=CC=CC=C4)(C5=CC=CC=C5)CC3.Cl

Molecular Formula

C36H40ClN3O6

Molecular Weight

646.17

References & Citations

[1]Eltze M, et al., Stereoselective inhibition of thromboxane-induced coronary vasoconstriction by 1,4-dihydropyridine calcium channel antagonists. Chirality. 1990;2 (4) :233-40.