M3227G (5) ppp (5') Am
M3227G (5) ppp (5') Am is a specific mRNA molecule structure, which is composed of a 3227-methylguanine (m3227G) cap, a triphosphate group and a 2'-O-methyladenosine. Am is a reversible modification located on the first coding nucleotide near the 5' cap of mRNA, that can affect the stability of mRNA[1].
Product Specifications
CAS Number
[178422-14-5]
UNSPSC
12352005
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/m3227g-5-ppp-5-am.html
Smiles
O=C1C2=C(N([C@H]3[C@H](O)[C@H](O)[C@@H](COP(OP(OP(OC[C@H]4O[C@@H](N(C=N5)C6=C5C(N)=NC=N6)[C@H](OC)[C@@H]4O)(O)=O)(O)=O)([O-])=O)O3)C=[N+]2C)NC(N(C)C)=N1
Molecular Formula
C24H35N10O17P3
Molecular Weight
828.51
References & Citations
[1]Mauer J, et al., Reversible methylation of m6Am in the 5' cap controls mRNA stability. Nature. 2017 Jan 19;541 (7637) :371-375.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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