SR1001
SR1001 is a selective RORα and RORγt inverse agonist with Kis 172 and 111 nM, respectively.
Product Specifications
CAS Number
1335106-03-0
UNSPSC
12352005
Hazard Statement
H302, H319
Target
REV-ERB; ROR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/SR1001.html
Purity
99.86
Solubility
DMSO : ≥ 39 mg/mL
Smiles
CC(NC1=NC(C)=C(S(=O)(NC2=CC=C(C(C(F)(F)F)(O)C(F)(F)F)C=C2)=O)S1)=O
Molecular Formula
C15H13F6N3O4S2
Molecular Weight
477.40
Precautions
H302, H319
References & Citations
[1]Solt LA, et al. Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand. Nature. 2011 Apr 28;472 (7344) :491-4.|[2]Crumbley C, et al. Regulation of expression of citrate synthase by the retinoic acid receptor-related orphan receptor α (RORα) . PLoS One. 2012;7 (4) :e33804.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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