SR1001

SR1001 is a selective RORα and RORγt inverse agonist with Kis 172 and 111 nM, respectively.

Product Specifications

CAS Number

[1335106-03-0]

UNSPSC

12352005

Hazard Statement

H302, H319

Target

REV-ERB; ROR

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/SR1001.html

Purity

99.86

Solubility

DMSO : ≥ 39 mg/mL

Smiles

CC(NC1=NC(C)=C(S(=O)(NC2=CC=C(C(C(F)(F)F)(O)C(F)(F)F)C=C2)=O)S1)=O

Molecular Formula

C15H13F6N3O4S2

Molecular Weight

477.40

Precautions

H302, H319

References & Citations

[1]Solt LA, et al. Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand. Nature. 2011 Apr 28;472 (7344) :491-4.|[2]Crumbley C, et al. Regulation of expression of citrate synthase by the retinoic acid receptor-related orphan receptor α (RORα) . PLoS One. 2012;7 (4) :e33804.