Diphenhydramine
Product Specifications
UNSPSC Description
Diphenhydramine is a first-generation histamine H1-receptor antagonist with anti-cholinergic effect. Diphenhydramine hydrochloride can across the ovine blood-brain barrier (BBB) [1][2][3].
Target Antigen
Bacterial; Endogenous Metabolite; Histamine Receptor; iGluR
Type
Reference compound
Related Pathways
Anti-infection;GPCR/G Protein;Immunology/Inflammation;Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease;Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/diphenhydramine.html
Purity
99.08
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CN(C)CCOC(C1=CC=CC=C1)C2=CC=CC=C2
Molecular Weight
255.361
References & Citations
[1]Jason P Berninger, et al. Effects of the antihistamine diphenhydramine on selected aquatic organisms. Environ Toxicol Chem. 2011 Sep;30(9):2065-72.|[2]Föhr KJ, et al. Open channel block of NMDA receptors by diphenhydramine. Neuropharmacology. 2015 Dec;99:459-70. |[3]Ehling S, et al. Diphenhydramine pharmacokinetics after oral and intravenous administration of diphenhydramine and oral administration of dimenhydrinate to healthy dogs, and pharmacodynamic effect on histamine-induced wheal formation: a pilot study. Vet Dermatol. 2019 Apr;30(2):91-e24. |[4]Hamano H, et al. Diphenhydramine may be a preventive medicine against cisplatin-induced kidney toxicity. Kidney Int. 2021 Apr;99(4):885-899. Acta Pharmacol Sin.2024 May 24.|Cell Rep Methods. 2023 Oct 23;3(10):100599.|Cell Rep. 2022 Nov 8;41(6):111615.|Chemosphere. 2019 Jun;225:378-387. |Pharmacol Res Perspect. 2021 Oct;9(5):e00879.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-B0303/Diphenhydramine-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-B0303/Diphenhydramine-SDS-MedChemExpress.pdf
Clinical Information
Launched
CAS Number
58-73-1
Available Sizes
Curated Selection
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