Scorpion toxin Tf2
Product Specifications
UNSPSC Description
Scorpion toxin Tf2 is a β-scorpion toxin, which is firstly identified in the venom of the Brazilian scorpion Tityus fasciolatus. Scorpion toxin Tf2 is a Nav1.3 activator, which is a neuronal voltage-gated sodium (Nav) subtype implicated in epilepsy and nociception. Scorpion toxin Tf2 enhances hNav1.3 activation voltage and opens the channel at resting membrane potentials[1].
Target Antigen
Sodium Channel
Type
Peptides
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/scorpion-toxin-tf2.html
Solubility
10 mM in DMSO
Smiles
O=C(N[C@@H](CCC(O)=O)C(NCC(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@@H](C)C(N[C@@H](CCSC)C(N[C@@H](CC(O)=O)C(N[C@@H](CC2=CNC=N2)C(N[C@@H](CCC(O)=O)C(NCC(N[C@@H](CSSC[C@@H](C(N)=O)NC3=O)C(N[C@@H](CCCCN)C(N[C@@H](CC4=CC=CC=C4)C(N[C@@H](CO)C(N[C@@H](CSSC[C@@H](C(N[C@@H](C)C(N[C@@H](CC5=CNC6=CC=CC=C56)C(N7[C@@H](CCC7)C(N[C@H]8C)=O)=O)=O)=O)NC9=O)C(N[C@@H](CC%10=CC=CC=C%10)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCCNC(N)=N)C(N%11[C@@H](CCC%11)C(N[C@@H](CO)C(NCC(N[C@@H](CC%12=CC=CC=C%12)C(N[C@@H](CSSC[C@@H](C(N[C@H]%13CC%14=CC=C(C=C%14)O)=O)NC8=O)C(N[C@@H](CC(O)=O)C(NCC(N[C@@H](CC%15=CC=C(C=C%15)O)C(N[C@@H](CSSC[C@@H](C(N[C@@H](CC%16=CC=C(C=C%16)O)C(NCC(N[C@@H](C(C)C)C(N%17[C@@H](CCC%17)C(N[C@@H](CO)C(N[C@@H](CC(N)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCCCN)C(N[C@@H](C(C)C)C(N[C@@H](CC%18=CNC%19=CC=CC=C%18%19)C(N[C@@H](CC(O)=O)C(N[C@@H](CC%20=CC=C(C=C%20)O)C(N[C@@H](C)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(N)=O)C(N[C@H]3CCCCN)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)NC%13=O)C(N[C@@H](CCCCN)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC%21=CNC=N%21)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N[C@@H](C)C(N[C@@H](CO)C(N[C@@H](CO)C(NCC(N[C@H]9CC%22=CC=C(C=C%22)O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCCCN)N
Molecular Weight
6953.86
References & Citations
[1]Camargos TS, et al. The Scorpion Toxin Tf2 from Tityus fasciolatus Promotes Nav1.3 Opening. PLoS One. 2015 Jun 17;10(6):e0128578.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-P5152/Scorpion-toxin-Tf2-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-P5152/
Clinical Information
No Development Reported
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