KRAS G12C inhibitor 63
KRAS G12C inhibitor 63 (K45) is a KRAS G12C inhibitor. KRAS G12C inhibitor 63 can induce Apoptosis. KRAS G12C inhibitor 63 has antitumor activity[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Ras
Type
Reference compound
Related Pathways
Apoptosis; GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/kras-g12c-inhibitor-63.html
Solubility
10 mM in DMSO
Smiles
COC1=CC(C2=C(Cl)C=C3C(OC(C=C3N4CCN(C(CCl)=O)[C@H](C)C4)=O)=C2)=C5C=CC=CC5=C1
Molecular Formula
C27H24Cl2N2O4
Molecular Weight
511.40
References & Citations
[1]Shi JT, et al. Discovery of novel coumarin-based KRAS-G12C inhibitors from virtual screening and Rational structural optimization. Bioorg Chem. 2024 Jul;148:107467.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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