M199
M199 is a potent TLR3/TLR9 signaling inhibitor. M199 induces secretion of IL-6, IL-8 and TNFα in human PBMCs. M199 is used as a selective inducer of the immune response[1].
Product Specifications
CAS Number
1051933-86-8
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Interleukin Related; TNF Receptor; Toll-like Receptor (TLR)
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/m199.html
Purity
98.55
Solubility
DMSO : 5.83 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(NCC)NC1=CC2=C(N=C3C=CC=CC3=C2C=C1)C
Molecular Formula
C17H17N3O
Molecular Weight
279.34
Precautions
H302, H315, H319, H335
References & Citations
[1]Natalija Knežević Teofilović, et al. 1-ethyl-3- (6-methylphenanthridine-8-il) urea modulates TLR3/9 activation and induces selective pro-inflammatory cytokine expression in vitro. Bioorg Med Chem Lett. 2017 Apr 1;27 (7) :1530-1537.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IL-6; IL-8; TLR3; TLR9
Available Sizes
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