Human Tyk2 Protein, His Tag (active enzyme)
Tyk2 was the first member of the JAK family that was described (the other members are JAK1, JAK2, and JAK3) . It has been implicated in IFN-α, IL-6, IL-10 and IL-12 signaling. Tyk2 functions primarily in IL-12 and type I-IFN signaling. Tyk2 deficiency has more dramatic effects in human cells than in mouse cells. However, in addition to IFN-α and -β and IL-12 signaling, Tyk2 has major effects on the transduction of IL-23, IL-10, and IL-6 signals. Recently, it has been recognized that IL-12 and IL-23 share ligand and receptor subunits that activate Tyk2. Tyk2 is activated by IL-10, and its deficiency affects the ability to generate and respond to IL-10.
Product Specifications
Background
Specifications
This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 38.5 kDa.
Accession Number
P29597-1
Expression Region
Pro 871 - Cys 1187
Host
Insect Cells
Target
Tyk2
Conjugation
Unconjugated
Tag
N-10xHis
Source
Human
Stability
The product MUST be stored at -70°C or lower upon receipt; -70°C for 3 months under sterile conditions.
Endotoxin
1.0 EU per μg
Format
Liquid
Buffer
50 mM Tris, 150 mM NaCl, pH7.5
Additives
Glycerol
Molecular Weight
38.5 kDa
Additionnal Information
Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/support/shipping-and-payments
Shipping Conditions
Dry ice
Storage Conditions
-70°C
Package Size
1mg*1
Host or Source
InsectCells
Species
Human
Protein ID
P29597-1
Preservative
Glycerol
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