BOC-FlFlF (TFA)
BOC-FlFlF (TFA) (Boc-Phe-dLeu-Phe-dLeu-Phe (TFA) ) is a selective FPR1 antagonist. BOC-FlFlF has an apparent dissociation constant (KD) of 230 nM as determined by the intracellular calcium mobilization assay. BOC-FlFlF can be used for the study of inflammation[1].
Product Specifications
Product Name Alternative
BOC2 (TFA) ; Boc-Phe-dLeu-Phe-dLeu-Phe (TFA)
UNSPSC
12352209
Target
Formyl Peptide Receptor (FPR)
Type
Peptides
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/boc-phe-leu-phe-leu-phe-tfa.html
Solubility
10 mM in DMSO
Smiles
O=C(O)[C@H](CC1=CC=CC=C1)NC([C@@H](CC(C)C)NC([C@H](CC2=CC=CC=C2)NC([C@@H](CC(C)C)NC([C@H](CC3=CC=CC=C3)NC(OC(C)(C)C)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O
Molecular Formula
C46H60F3N5O10
Molecular Weight
899.99
References & Citations
[1]Hayashi R, et al. Development of potent antagonists for formyl peptide receptor 1 based on Boc-Phe-D-Leu-Phe-D-Leu-Phe-OH. Bioorg Med Chem. 2014 Aug 1;22 (15) :3824-8.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Frequently Asked Questions
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