Antiviral agent 52

Antiviral agent 52 (Compound 30) is a Chlorcyclizine (HY-112067) derivative that exhibits antiviral activity against hepatitic C virus (HCV) with an EC50 of 17 nM. Antiviral agent 52 reveals cytotoxicity in cell Huh7.5.1 with CC50 of 21.3 μM[1].

Product Specifications

CAS Number

[101784-44-5]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

HCV

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/antiviral-agent-52.html

Solubility

10 mM in DMSO

Smiles

CN1CCN(C(C2=CC=C(Cl)C=C2)C3=CC=C(Cl)C=C3)CC1

Molecular Formula

C18H20Cl2N2

Molecular Weight

335.27

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]He S, et al., Discovery, Optimization, and Characterization of Novel Chlorcyclizine Derivatives for the Treatment of Hepatitis C Virus Infection. J Med Chem. 2016 Feb 11;59 (3) :841-53.