ZK53
ZK53 is a selective activator of mitochondrial caseinolytic protease P (HsClpP) (EC50: 1.37 μM for α-casein hydrolysis by HsClpP) . ZK53 is is inactive toward bacterial ClpP proteins. ZK53 induces apoptosis in H1703, H520 and SK-MES-1 cells. ZK53 induces dysregulation of mitochondrial functions in lung squamous cell carcinoma (LUSC) cells. ZK53 inhibits tumor growth in H1703 xenograft mouse model[1].
Product Specifications
CAS Number
[3031789-26-8]
UNSPSC
12352005
Target
Mitochondrial Metabolism
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/zk53.html
Purity
98.94
Solubility
DMSO : 200 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
FC1=CC(F)=CC(CN2CCN(C(NCC3=CC=C(Br)C=C3)=O)CC2)=C1
Molecular Formula
C19H20BrF2N3O
Molecular Weight
424.28
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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