VHL Protein Complex Active

<strong>VHL Protein Complex Active</strong>_x000D_ <strong>Catalog number:</strong> B2014230_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 5 µg_x000D_ <strong>Molecular Weight or Concentration:</strong> N/A_x000D_ <strong>Supplied as:</strong> Solution_x000D_ <strong>Applications:</strong> molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> ‚àí20¬∞C_x000D_ <strong>Keywords:</strong> VCB-Cul2 complex, ECV complex, CBC VHL_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MŒ©-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Maxwell PH, Wiesener MS, Chang GW, Clifford SC, Vaux EC, Cockman ME, Wykoff CC, Pugh CW, Maher ER, Ratcliffe PJ. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis Nature. 1999 May 20;399(6733):271-5._x000D_ 2: Gadd MS, Testa A, Lucas X, Chan KH, Chen W, Lamont DJ, Zengerle M, Ciulli A. Structural basis of PROTAC cooperative recognition for selective protein degradation Nat Chem Biol. 2017 May;13(5):514-521._x000D_ 3: Testa A, Hughes SJ, Lucas X, Wright JE, Ciulli A. Structure-Based Design of a Macrocyclic PROTAC Angew Chem Int Ed Engl. 2020 Jan 20;59(4):1727-1734._x000D_ 4: Ishida T, Ciulli A. E3 Ligase Ligands for PROTACs: How They Were Found and How to Discover New Ones SLAS Discov. 2021 Apr;26(4):484-502._x000D_ 5: Farnaby W, Koegl M, Roy MJ, Whitworth C, Diers E, Trainor N, Zollman D, Steurer S, Karolyi-Oezguer J, Riedmueller C, Gmaschitz T, Wachter J, Dank C, Galant M, Sharps B, Rumpel K, Traxler E, Gerstberger T, Schnitzer R, Petermann O, Greb P, Weinstabl H, Bader G, Zoephel A, Weiss-Puxbaum A, Ehrenhfer-Wlfer K, Whrle S, Boehmelt G, Rinnenthal J, Arnhof H, Wiechens N, Wu MY, Owen-Hughes T, Ettmayer P, Pearson M, McConnell DB, Ciulli A. BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design Nat Chem Biol. 2019 Jul;15(7):672-680._x000D_ 6: Imaide S, Riching KM, Makukhin N, Vetma V, Whitworth C, Hughes SJ, Trainor N, Mahan SD, Murphy N, Cowan AD, Chan KH, Craigon C, Testa A, Maniaci C, Urh M, Daniels DL, Ciulli A. Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity Nat Chem Biol. 2021 Nov;17(11):1157-1167._x000D_ 7: Cancer Genome Atlas Research Network. Comprehensive molecular characterization of clear cell renal cell carcinoma Nature. 2013 Jul 4;499(7456):43-9._x000D_ 8: Feng R, Mayuranathan T, Huang P, Doerfler PA, Li Y, Yao Y, Zhang J, Palmer LE, Mayberry K, Christakopoulos GE, Xu P, Li C, Cheng Y, Blobel GA, Simon MC, Weiss MJ. Activation of _-globin expression by hypoxia-inducible factor 1 Nature. 2022 Oct;610(7933):783-790._x000D_ 9: Li G, Ko CN, Li D, Yang C, Wang W, Yang GJ, Di Primo C, Wong VKW, Xiang Y, Lin L, Ma DL, Leung CH. A small molecule HIF-1 stabilizer that accelerates diabetic wound healing Nat Commun. 2021 Jun 7;12(1):3363._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/34586829">10: Yu X, Li D, Kottur J, Shen Y, Kim HS, Park KS, Tsai YH, Gong W, Wang J, Suzuki K, Parker J, Herring L, Kaniskan H, Cai L, Jain R, Liu J, Aggarwal AK, Wang GG, Jin J. A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models Sci Transl Med. 2021 Sep 29;13(613):eabj1578. </a>_x000D_ _x000D_ <strong>Products Related to VHL Protein Complex Active can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>