BChE-IN-28

BChE-IN-28 (compound 6J) is a selective butyrylcholinesterase (BChE) inhibitor with an IC50 of 8 nM and a Ki of 12.16 nM. BChE-IN-28 shows the lower inhibition against AChE, MAO-A and MAO-B[1].

Product Specifications

UNSPSC

12352005

Target

Cholinesterase (ChE)

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/bche-in-28.html

Solubility

10 mM in DMSO

Smiles

S=C(NS(=O)(C1=CC=C(C=C1)C)=O)NC(S2)=NC3=C2C=C(C(OCCCC(C)C)=O)C=C3

Molecular Formula

C22H25N3O4S3

Molecular Weight

491.65

References & Citations

[1]Nguyen Dinh Thanh, et al. Sulfonyl thioureas with a benzo[d]thiazole ring as dual acetylcholinesterase/butyrylcholinesterase and human monoamine oxidase A and B inhibitors: An in vitro and in silico study. Arch Pharm (Weinheim) . 2024 Feb 6:e2300557.