(S) -Indoximod-d3
(S) -Indoximod-d3 is the deuterium labeled (S) -Indoximod. (S) -Indoximod (1-Methyl-L-tryptophan) is an inhibitor of indoleamine 2,3-dioxygenase (IDO) . (S) -Indoximod can be used for the research of cancer[1][2][3].
Product Specifications
CAS Number
1801851-87-5
Product Name Alternative
1-Methyl-L-tryptophan-d3; (S) -NLG-8189-d3
UNSPSC
12352005
Target
Indoleamine 2,3-Dioxygenase (IDO)
Type
Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer
Purity
99.0
Solubility
10 mM in DMSO|DMSO : 4.81mg/mL (ultrasonic; warming; adjust pH to 4 with HCl; heat to 60°C)
Smiles
N[C@@H](CC1=CN(C([2H])([2H])[2H])C2=CC=CC=C12)C(O)=O
Molecular Formula
C12H11D3N2O2
Molecular Weight
221.27
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Huang GL, et, al. PEG-Poly (1-Methyl-l-Tryptophan) -Based Polymeric Micelles as Enzymatically Activated Inhibitors of Indoleamine 2,3-Dioxygenase. Nanomaterials (Basel) . 2019 May 9;9 (5) :719.|[3]Liu X, et, al. 1-L-MT, an IDO inhibitor, prevented colitis-associated cancer by inducing CDC20 inhibition-mediated mitotic death of colon cancer cells. Int J Cancer. 2018 Sep 15;143 (6) :1516-1529.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Available Sizes
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