20-HEDE

20-HEDE (WIT 002) is an antagonist of 20-hydroxyeicosatetraenoic acid (20-HETE) .

Product Specifications

CAS Number

[240427-90-1]

Product Name Alternative

WIT 002

UNSPSC

12352211

Hazard Statement

H315, H319

Target

Others

Type

Reference compound

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/WIT_002.html

Purity

98.0

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(O)CCCC/C=C\CCCCCCC/C=C\CCCCO

Molecular Formula

C20H36O3

Molecular Weight

324.50

Precautions

H315, H319

References & Citations

[1]Ming Yua . et al. Effects of a 20-HETE antagonist and agonists on cerebral vascular tone. Eur J Pharmacol. 2004 Feb 23;486 (3) :297-306.|[2]Wei Yu, et al. Cytochrome P450 ω-hydroxylase promotes angiogenesis and metastasis by upregulation of VEGF and MMP-9 in non-small cell lung cancer. Cancer Chemother Pharmacol. 2011 Sep; 68 (3) : 619-29.|[3]Anna Alexanian, et al. Down-regulation of 20-HETE Synthesis and Signaling Inhibits Renal Adenocarcinoma Cell Proliferation and Tumor Growth. Anticancer Res. 2009 October ; 29 (10) : 3819-3824.