Cefuroxime axetil

Cefuroxime axetil is an orally effective broad-spectrum β-lactam antibiotic that targets bacterial penicillin-binding proteins (PBPs, such as PBP3 and PBP1) . Cefuroxime axetil inhibits cell wall synthesis, leading to bacterial lysis and death, with a minimum inhibitory concentration (MIC) of 0.12-4 mg/L for non-typeable Haemophilus influenzae (NTHi) . Cefuroxime axetil is hydrolyzed by esterase to the active ingredient Cefuroxime (HY-B1256A) after oral absorption. Topical administration of Cefuroxime via bioadhesive nanoparticles (BNPs) can prolong the drug's retention time in the middle ear (≥7 days) . Cefuroxime axetil can be used in the study of otitis media (especially NTHi infection) . Cefuroxime axetil can achieve precise antibacterial effects through oral or topical nano-delivery systems, reducing systemic exposure and the risk of antibiotic resistance[1][2][3].

Product Specifications

CAS Number

[64544-07-6]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Antibiotic; Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/cefuroxime-axetil.html

Purity

99.53

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(C(N12)=C(COC(N)=O)CS[C@]2([H])[C@H](NC(/C(C3=CC=CO3)=N\OC)=O)C1=O)OC(OC(C)=O)C

Molecular Formula

C20H22N4O10S

Molecular Weight

510.47

Precautions

H302, H315, H319, H335

References & Citations

[1]Scott LJ, et al. Cefuroxime axetil: an updated review of its use in the management of bacterial infections. Drugs. 2001;61 (10) :1455-500.|[2]Lin H, et al. In Vivo Evaluation of Cefuroxime Axetil-Loaded Bioadhesive Nanoparticles to Treat Haemophilus influenzae-Induced Otitis Media. Front Bioeng Biotechnol. 2022 Apr 29;10:884797.|[3]Dafale Nishant A, et al. Development and validation of microbial bioassay for the quantification of potency of the antibiotic cefuroxime axetil. Analytical Methods 5.3 (2013) : 690-698.