EGFR/VEGFR2-IN-3
Product Specifications
UNSPSC Description
EGFR/VEGFR2-IN-3 (compound 9) is a potent EGFR and VEGFR-2 inhibitor with IC50 values of 0.129, 0.142, 3.428 µM for EGFR, VEGFR-2, COX-2, respectively. EGFR/VEGFR2-IN-3 shows cytotoxicity. EGFR/VEGFR2-IN-3 induces apoptosis and cell cycle arrest at G2/M phase[1].
Target Antigen
Apoptosis; EGFR; VEGFR
Type
Reference compound
Related Pathways
Apoptosis;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-vegfr2-in-3.html
Smiles
CC1=CC=C(C=C1)NC(NNC(CSC2=NC3=CC=CC=C3C(N2C4=CC=C(C=C4)Cl)=O)=O)=S
Molecular Weight
510.03
References & Citations
[1]Hamdi A, et al. Harnessing potential COX-2 engagement for boosting anticancer activity of substituted 2-mercapto-4(3H)-quinazolinones with promising EGFR/VEGFR-2 inhibitory activities. Bioorg Chem. 2024 Nov 12;153:107951.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-168655/EGFR-VEGFR2-IN-3-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-168655/
Clinical Information
No Development Reported
CAS Number
710972-61-5
Curated Selection
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