EGFR/VEGFR2-IN-3

EGFR/VEGFR2-IN-3 (compound 9) is a potent EGFR and VEGFR-2 inhibitor with IC50 values of 0.129, 0.142, 3.428 µM for EGFR, VEGFR-2, COX-2, respectively. EGFR/VEGFR2-IN-3 shows cytotoxicity. EGFR/VEGFR2-IN-3 induces apoptosis and cell cycle arrest at G2/M phase[1].

Product Specifications

CAS Number

[710972-61-5]

UNSPSC

12352211

Target

Apoptosis; EGFR; VEGFR

Type

Reference compound

Related Pathways

Apoptosis; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/egfr-vegfr2-in-3.html

Smiles

CC1=CC=C(C=C1)NC(NNC(CSC2=NC3=CC=CC=C3C(N2C4=CC=C(C=C4)Cl)=O)=O)=S

Molecular Formula

C24H20ClN5O2S2

Molecular Weight

510.03

References & Citations

[1]Hamdi A, et al. Harnessing potential COX-2 engagement for boosting anticancer activity of substituted 2-mercapto-4 (3H) -quinazolinones with promising EGFR/VEGFR-2 inhibitory activities. Bioorg Chem. 2024 Nov 12;153:107951.