MMV1557817
MMV1557817 is an orally active and potent antimalarial compound. MMV1557817 is a selective, nanomolar inhibitor of both Plasmodium falciparum and Plasmodium vivax aminopeptidases M1 and M17, leading to inhibition of end-stage hemoglobin digestion in asexual parasites[1].
Product Specifications
CAS Number
2065197-82-0
UNSPSC
12352005
Target
Parasite
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/mmv1557817.html
Smiles
CC(C)(CC(NC(C1=CC=C(C=C1)C2=CC(F)=C(C(F)=C2)F)C(NO)=O)=O)C
Molecular Formula
C20H21F3N2O3
Molecular Weight
394.39
References & Citations
[1]Edgar RCS, et al. On-target, dual aminopeptidase inhibition provides cross-species antimalarial activity. mBio. 2024 Jun 12;15 (6) :e0096624.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Plasmodium
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