UNC8153
UNC8153 is a potent and selective nuclear receptor-binding SET domain-containing 2 (NSD2) -targeted degrader with a Kd of 24 nM. UNC8153 reduces the cellular levels of both NSD2 protein (DC50 in cell U2OS is 0.35 μM) and the H3K36me2 chromatin mark. UNC8153 contains a simple warhead that confers proteasome-dependent degradation of NSD2[1].
Product Specifications
UNSPSC
12352005
Target
Histone Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/unc8153.html
Purity
99.13
Smiles
O=C(C1=CC=C2NC(COC2=C1)=O)N(CC3=CC=C(C(NC4=CC=C(C(NCCCCCCN)=O)C=C4)=O)C=C3)C5CC5
Molecular Formula
C33H37N5O5
Molecular Weight
583.68
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-157251A/UNC8153-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-157251A/UNC8153-SDS-MedChemExpress.pdf
Scientific Category
Reference compound1
Clinical Information
No Development Reported
CAS Number
[2929304-60-7]
Available Sizes
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
![Mouse Monoclonal Lipocalin-2/NGAL Antibody (972737) [Alexa Fluor 594]](https://cdn.genprice.uk/genprice/genprice3.png)
Mouse Monoclonal Lipocalin-2/NGAL Antibody (972737) [Alexa Fluor 594]
![P18 INK4c (CDKN2C) Mouse Monoclonal Antibody [Clone:1C12]](https://cdn.genprice.uk/genprice/genprice2.png)