UNC8153
UNC8153 is a potent and selective nuclear receptor-binding SET domain-containing 2 (NSD2) -targeted degrader with a Kd of 24 nM. UNC8153 reduces the cellular levels of both NSD2 protein (DC50 in cell U2OS is 0.35 μM) and the H3K36me2 chromatin mark. UNC8153 contains a simple warhead that confers proteasome-dependent degradation of NSD2[1].
Product Specifications
CAS Number
2929304-60-7
UNSPSC
12352005
Target
Histone Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/unc8153.html
Purity
99.13
Smiles
O=C(C1=CC=C2NC(COC2=C1)=O)N(CC3=CC=C(C(NC4=CC=C(C(NCCCCCCN)=O)C=C4)=O)C=C3)C5CC5
Molecular Formula
C33H37N5O5
Molecular Weight
583.68
References & Citations
[1]Ronan P Hanley, et al. Discovery of a Potent and Selective Targeted NSD2 Degrader for the Reduction of H3K36me2. J Am Chem Soc. 2023 Apr 12;145 (14) :8176-8188.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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