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FAK-IN-20

FAK-IN-20 (Compound 7b) is an inhibitor of FAK with an IC50 value of 0.27 nM. FAK-IN-20 exhibits anticancer activity. FAK-IN-20 can arrest the cell cycle in the G2/M phase and induce cell apoptosis by generating ROS[1].

Product Specifications

CAS Number

[3004967-41-0]

UNSPSC

12352005

Target

Apoptosis; FAK

Type

Reference compound

Related Pathways

Apoptosis; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/fak-in-20.html

Solubility

10 mM in DMSO

Smiles

O=C(NC)C1=CC=CC=C1NC2=C(Cl)C=NC(NC3=C(OC)C=C(NS(CCN4C[C@@H](C)O[C@@H](C)C4)(=O)=O)C=C3)=N2

Molecular Formula

C27H34ClN7O5S

Molecular Weight

604.12

References & Citations

[1]Li R, et al. Discovery of 2,4-diarylaminopyrimidine derivatives bearing sulfonamide moiety as novel FAK inhibitors. Bioorg Chem. 2024;144:107134.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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