FAK-IN-20
FAK-IN-20 (Compound 7b) is an inhibitor of FAK with an IC50 value of 0.27 nM. FAK-IN-20 exhibits anticancer activity. FAK-IN-20 can arrest the cell cycle in the G2/M phase and induce cell apoptosis by generating ROS[1].
Product Specifications
CAS Number
[3004967-41-0]
UNSPSC
12352005
Target
Apoptosis; FAK
Type
Reference compound
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/fak-in-20.html
Solubility
10 mM in DMSO
Smiles
O=C(NC)C1=CC=CC=C1NC2=C(Cl)C=NC(NC3=C(OC)C=C(NS(CCN4C[C@@H](C)O[C@@H](C)C4)(=O)=O)C=C3)=N2
Molecular Formula
C27H34ClN7O5S
Molecular Weight
604.12
References & Citations
[1]Li R, et al. Discovery of 2,4-diarylaminopyrimidine derivatives bearing sulfonamide moiety as novel FAK inhibitors. Bioorg Chem. 2024;144:107134.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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