Neuraminidase-IN-20
Neuraminidase-IN-20 (Compound 5i) is a potent inhibitor of mutant neuraminidase (NA) (H5N1-H274Y) (IC50= 0.44 μM) .Neuraminidase-IN-20 binds to the 430 cavity site of NA and disrupts the enzymatic activity of NA[1].
Product Specifications
UNSPSC
12352005
Target
Influenza Virus
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/neuraminidase-in-20.html
Solubility
10 mM in DMSO
Smiles
C/C(C1=CC=C(C=C1)NC(CC2=CC=CS2)=O)=N\NC(C3=CC=C(C=C3)F)=O
Molecular Formula
C21H18FN3O2S
Molecular Weight
395.45
References & Citations
[1]Fu SK, et al.Discovery andsynthesis of novel benzoylhydrazone neuraminidase inhibitors. Bioorg Med Chem Lett. 2024 Jun 1;105:129743.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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