IU1-248
IU1-248, a derivative of IU1, is a potent and selective USP14 inhibitor with an IC50 of 0.83 μM.
Product Specifications
UNSPSC
12352005
Hazard Statement
H302, H312, H315, H319, H332, H335
Target
Deubiquitinase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/iu1-248.html
Purity
99.19
Solubility
DMSO : 83.33 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
N#CC1=CC=C(N2C(C)=C(C(CN3CCC(O)CC3)=O)C=C2C)C=C1
Molecular Formula
C20H23N3O2
Molecular Weight
337.42
Precautions
H302, H312, H315, H319, H332, H335
References & Citations
[1]Yiwei Wang, et al. Small molecule inhibitors reveal allosteric regulation of USP14 via steric blockade. Cell Res. 2018 Dec;28 (12) :1186-1194.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-122885/IU1-248-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-122885/IU1-248-SDS-MedChemExpress.pdf
Scientific Category
Reference compound1
Clinical Information
No Development Reported
CAS Number
[2307472-03-1]
Available Sizes
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