IU1-248
Product Specifications
UNSPSC Description
IU1-248, a derivative of IU1, is a potent and selective USP14 inhibitor with an IC50 of 0.83?μM.
Target Antigen
Deubiquitinase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/iu1-248.html
Purity
99.19
Solubility
DMSO : 83.33 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
N#CC1=CC=C(N2C(C)=C(C(CN3CCC(O)CC3)=O)C=C2C)C=C1
Molecular Weight
337.42
References & Citations
[1]Yiwei Wang, et al. Small molecule inhibitors reveal allosteric regulation of USP14 via steric blockade. Cell Res. 2018 Dec;28(12):1186-1194.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-122885/IU1-248-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-122885/IU1-248-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2307472-03-1
Available Sizes
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