IU1-248
IU1-248, a derivative of IU1, is a potent and selective USP14 inhibitor with an IC50 of 0.83 μM.
Product Specifications
CAS Number
[2307472-03-1]
UNSPSC
12352005
Hazard Statement
H302, H312, H315, H319, H332, H335
Target
Deubiquitinase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/iu1-248.html
Purity
99.19
Solubility
DMSO : 83.33 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
N#CC1=CC=C(N2C(C)=C(C(CN3CCC(O)CC3)=O)C=C2C)C=C1
Molecular Formula
C20H23N3O2
Molecular Weight
337.42
Precautions
H302, H312, H315, H319, H332, H335
References & Citations
[1]Yiwei Wang, et al. Small molecule inhibitors reveal allosteric regulation of USP14 via steric blockade. Cell Res. 2018 Dec;28 (12) :1186-1194.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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