Cyclamic acid (sodium)

Cyclamic acid sodium (Sodium cyclamate) is a commonly used sweetener. Cyclamic acid sodium is toxic to osteoblasts and can inhibit cell proliferation, induce apoptosis and reduce cell mineralization. Cyclamic acid sodium causes focal necrosis of bladder organs in rats in vitro, which can promote bladder cancer, but some studies have shown that low doses of Cyclamic acid sodium have no carcinogenic effect. In addition, Cyclamic acid sodium has no effect on insulin and glucagon secretion induced by arginine[1][2][3][4][5].

Product Specifications

CAS Number

[139-05-9]

Product Name Alternative

Sodium cyclamate; Cyclohexylsulfamic acid (sodium)

UNSPSC

12352211

Hazard Statement

H302

Target

Apoptosis; Necroptosis

Type

Reference compound

Related Pathways

Apoptosis

Field of Research

Cancer; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/cyclamic-acid-sodium.html

Purity

99.43

Solubility

DMSO : 20 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 50 mg/mL (ultrasonic)

Smiles

O=S(NC1CCCCC1)(O[Na])=O

Molecular Formula

C6H12NNaO3S

Molecular Weight

201.22

Precautions

H302

References & Citations

[1]Leban I, et, al. Structures of artificial sweeteners--cyclamic acid and sodium cyclamate with other cyclamates. Acta Crystallogr B. 2007 Jun;63 (Pt 3) :418-25.|[2]Knowles MA, Jani H, Hicks RM. Induction of morphological changes in the urothelium of cultured adult rat bladder by sodium saccharin and sodium cyclamate. Carcinogenesis. 1986 May;7 (5) :767-74.|[3]Chen Z, et al. Toxicity of food sweetener-sodium cyclamate on osteoblasts cells. Biochem Biophys Res Commun. 2019 Jan 8;508 (2) :507-511.|[4]Brantom PG, et al. Long-term toxicity of sodium cyclamate in mice. Food Cosmet Toxicol. 1973 Oct;11 (5) :735-46.|[5]Usami M, et al. Effect of cyclamate sodium, saccharin sodium and stevioside on arginine-induced insulin and glucagon secretion in the isolated perfused rat pancreas. Horm Metab Res. 1980 Dec;12 (12) :705-6.