(E/Z) -GSK-3β inhibitor 1

(E/Z) -GSK-3β inhibitor 1 is a racemic compound of (E) -GSK-3β inhibitor 1 and (Z) -GSK-3β inhibitor 1 isomers. GSK-3β inhibitor 1 (compound 3a) is a glycogen synthase kinase 3β (GSK-3β) inhibitor and demonstrates high antidiabetic efficacy, with an IC50 of 4.9 nM[1].

Product Specifications

CAS Number

[3367-88-2]

UNSPSC

12352005

Hazard Statement

H315, H319

Target

GSK-3

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR; Stem Cell/Wnt

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/e-z-gsk-3β-inhibitor-1.html

Purity

99.10

Solubility

DMSO : 50 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL

Smiles

O=C1NC2=C(C=CC=C2)/C1=C/C3=NC=CC=C3

Molecular Formula

C14H10N2O

Molecular Weight

222.24

Precautions

H315, H319

References & Citations

[1]Lozinskaya NA, et al. Synthesis and biological evaluation of 3-substituted 2-oxindole derivatives as new glycogen synthase kinase 3β inhibitors. Bioorg Med Chem. 2019 May 1;27 (9) :1804-1817.