MK-0434
MK-0434 is an orally active steroid 5α-reductase inhibitor. MK-0434 specifically inhibits steroid 5α-reductase, thereby reducing the level of dihydrotestosterone (DHT) in the body. MK-0434 can be used in the study of benign prostatic hyperplasia[1].
Product Specifications
CAS Number
134067-56-4
UNSPSC
12352005
Target
5 alpha Reductase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/mk-0434.html
Smiles
C[C@@]12[C@H](CC[C@]1([C@@]3(CC[C@]4(NC(C=C[C@@]4([C@]3(CC2)[H])C)=O)[H])[H])[H])C(C5=CC=CC=C5)=O
Molecular Formula
C25H31NO2
Molecular Weight
377.52
References & Citations
[1]Van Hecken, et al. "Plasma concentrations and effect on testosterone metabolism after single doses of MK-0434, a steroid 5 alpha-reductase inhibitor, in healthy subjects." European journal of clinical pharmacology 46 (1994) : 123-126.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1
Available Sizes
Frequently Asked Questions
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