Propiomazine (hydrochloride)
Propiomazine hydrochloride is an orally active antihistamine agent with sedative effects. Propiomazine hydrochloride can be used in the research of insomnia[1][2].
Product Specifications
CAS Number
1240-15-9
UNSPSC
12352005
Target
Histamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
COVID-19-immunoregulation
Assay Protocol
https://www.medchemexpress.com/propiomazine-hydrochloride.html
Smiles
CCC(C1=CC=C(SC2=C3C=CC=C2)C(N3CC(C)N(C)C)=C1)=O.[H]Cl
Molecular Formula
C20H25ClN2OS
Molecular Weight
376.94
References & Citations
[1]B Midgren, et al. Effects of single doses of propiomazine, a phenothiazine hypnotic, on sleep and oxygenation in patients with stable chronic obstructive pulmonary disease. Respiration. 1990;57 (4) :239-42.|[2]Thunander Sundbom L, etal. Sedating antihistamines - risk of severe intoxication. Lakartidningen. 2021 Sep 30;118:21037.|[3]C.Bjerre, et al. Bioavailability of the sedative propiomazine after nasal administration in rats. International Journal of Pharmaceutics, 1996, 144 (2), 217-224.|[4]F T Serratoni, et al. Promethazine protection in carbon tetrachloride liver injury. An electron microscopic study. Arch Pathol. 1969 Jan;87 (1) :46-51.|[5]Fayez M, et al. Effect of propiomazine on plasma prolactin in the rat: counteraction by L-dopa. Proc Soc Exp Biol Med. 1985 Apr;178 (4) :606-9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched
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