ESI-08
ESI-08 is a potent and selective EPAC antagonist, which can completely inhibit both EPAC1 and EPAC2 (IC50 of 8.4 μM) activity. ESI-08 selectively blocks cAMP-induced EPAC activation, but does not inhibit cAMP-mediated PKA activation[1].
Product Specifications
CAS Number
301177-43-5
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Metabolic Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/esi-08.html
Purity
98.74
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
N#CC1=C(C2CCCCC2)N=C(SCC3=CC(C)=CC=C3C)NC1=O
Molecular Formula
C20H23N3OS
Molecular Weight
353.48
Precautions
H302, H315, H319
References & Citations
[1]Chen H, et al. 5-Cyano-6-oxo-1,6-dihydro-pyrimidines as potent antagonists targeting exchange proteins directly activated by cAMP. Bioorg Med Chem Lett. 2012 Jun 15;22 (12) :4038-43.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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