DD-03-156

DD-03-156 is a potent and selective degrader of CDK17 and LIMK2. The selectivity and potency of DD-03-156 is exquisite and makes an advanced starting point for the development of a chemical probe for the degradation of CDK17 (Blue: VHL ligand (HY-112078), Black: linker HY-124380 (HY-124380); Pink: BRAF inhibitor (HY-14660) ) [1].

Product Specifications

CAS Number

[2769753-69-5]

Product Name Alternative

(S, R, S) -AHPC-Me-PEG2-dabrafenib

UNSPSC

12352005

Target

CDK; LIM Kinase (LIMK) ; PROTACs

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; PROTAC

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/dd-03-156.html

Purity

99.90

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

CC(C)(C)C(S1)=NC(C2=CC=CC(NS(C3=C(F)C=CC=C3F)(=O)=O)=C2F)=C1C4=NC(NCCOCCOCCC(N[C@@H](C(C)(C)C)C(N5C[C@H](O)C[C@H]5C(N[C@@H](C)C6=CC=C(C7=C(C)N=CS7)C=C6)=O)=O)=O)=NC=C4