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N, O-Didansyl-L-tyrosine (cyclohexylammonium)

Selected Variant

HY-W142014

Size: 1 Each

N, O-Didansyl-L-tyrosine cyclohexylammonium is a potent selective thymidylate synthase (TS) inhibitor, acts on TS of Escherichia coli, Lactobacillus casei and human with the IC50 values of 5.0, 3.4 and 119 μM, respectively[1].

Product Specifications

CAS Number

102783-47-1

UNSPSC

12352209

Hazard Statement

H302-H315-H319-H335

Target

Thymidylate Synthase

Type

Peptides

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/n-o-didansyl-l-tyrosine-cyclohexylammonium.html

Solubility

10 mM in DMSO

Smiles

NC1CCCCC1.O=S(OC(C=C2)=CC=C2C[C@@H](C(O)=O)NS(=O)(C3=CC=CC4=C3C=CC=C4N(C)C)=O)(C5=CC=CC6=C5C=CC=C6N(C)C)=O

Molecular Formula

C39H46N4O7S2

Molecular Weight

746.94

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]T A Fritz, et al. Predicting and harnessing protein flexibility in the design of species-specific inhibitors of thymidylate synthase. Chem Biol. 2001 Oct;8 (10) :981-95.

Shipping Conditions

Room temperature

Scientific Category

Peptides

Clinical Information

No Development Reported

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