Bcl-2 Polyclonal Antibody
Product Specifications
Background
BCL2 (BCL2 Apoptosis Regulator) is a Protein Coding gene. Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) . Also acts as an inhibitor of autophagy: interacts with BECN1 and AMBRA1 during non-starvation conditions and inhibits their autophagy function. May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release.
Abbreviation
Bcl-2
UniProt
P49950
Host
Rabbit
Reactivity
Human
Immunogen
Recombinant Rat Bcl-2 protein expressed by E.coli
Target
PPP1R; PPP1R50; Bcl-2; Bcl2
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
IHC
Purification
Antigen Affinity Purification
Concentration
1 mg/mL
Dilution
IHC 1:100-1:200
Buffer
PBS with 0.02% sodium azide, 1% protective protein and 50% glycerol, pH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. Protected from prolonged exposure to light.
Isotype
IgG
Available Sizes
Documents
Curated Selection
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