DiMNF
DiMNF (3',4'-Dimethoxy-αNF) is a selective aryl hydrocarbon receptor (AHR) modulator. DiMNF is a competitive AHR ligand (IC50 = 21 nM) with apparent antagonistic activity. DiMNF can be used as an anti-inflammatory agent[1].
Product Specifications
CAS Number
[14756-24-2]
Product Name Alternative
3',4'-Dimethoxy-αNF
UNSPSC
12352005
Hazard Statement
H301
Target
Aryl Hydrocarbon Receptor
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/dimnf.html
Concentration
10mM
Purity
98.46
Solubility
DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 70°C)
Smiles
O=C1C2=CC=C3C=CC=CC3=C2OC(C4=CC=C(OC)C(OC)=C4)=C1
Molecular Formula
C21H16O4
Molecular Weight
332.35
Precautions
H301
References & Citations
[1]Murray IA, et al. Suppression of cytokine-mediated complement factor gene expression through selective activation of the Ah receptor with 3',4'-dimethoxy-α-naphthoflavone. Mol Pharmacol. 2011 Mar;79 (3) :508-19.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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