Chlorobutanol

Chlorobutanol is an orally active and potent inhibitor of platelet aggregation and release and a pharmaceutical preservative with antibacterial activity. Chlorobutanol inhibits thromboxane B2 formation, ATP release, and elevation of cytosolic free calcium caused by collagen, ADP, epinephrine, arachidonic acid and thrombin. Chlorobutanol is active against a wide variety of Gram-positive and Gram-negative bacteria, and several mold spores and fungi. Chlorobutanol is widely used in food and cosmetic industry[1][2][3][4].

Product Specifications

CAS Number

[57-15-8]

UNSPSC

12352211

Hazard Statement

H302

Target

Bacterial; Fungal

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/chlorobutanol.html

Purity

98.0

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC(O)(C)C(Cl)(Cl)Cl

Molecular Formula

C4H7Cl3O

Molecular Weight

177.46

Precautions

H302

References & Citations

[1]Smoak IW, et al. Chlorobutanol: maternal serum levels and placental transfer in the mouse. Vet Hum Toxicol. 1997 Oct;39 (5) :287-90.|[2]Friesen WT, et al. The antibacterial stability of chlorobutanol stored in polyethylene bottles. Am J Hosp Pharm. 1971 Jul;28 (7) :507-12.|[3]Chen SL, et al. Chlorobutanol, a preservative of desmopressin, inhibits human platelet aggregation and release in vitro. Thromb Haemost. 1990 Nov 30;64 (3) :473-7.|[4]Fischer M. Effects of chlorobutanol on primary and secondary endings of isolated cat muscle spindles. Brain Res. 2000 Jan 31;854 (1-2) :106-21.|[5]Jeong D, et al. In Vivo Evaluation of the Oral Toxicity of the Chlorobutanol. Toxics. 2022 Jan 7;10 (1) :24.